Botulinum Toxins

Receptor forClostridium botulinumType A Neurotoxin, GST-SV2c luminal domain
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Products are for research purposes only and are not for use in humans or as diagnostic agents.

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GST-SV2c contains amino acids 454-579 of the human SV2c protein.  This region of the protein is known as the luminal domain loop, between transmembrane domains 7 and 8, and has been shown to be the location of botulinum neurotoxin type A (BoNT/A) binding.  Three posters demonstrating the functionality of the GST-SV2c fusion protein as a receptor for BoNT/A are available on this website (poster tab).  Recent data from our laboratory indicate improved specificity and reliable detection of as little as 1.25 pg BoNT/A when captured by the SV2c receptor. A full description of the optimized parameters will be available soon.