PERTUSSIS TOXIN MUTANT
List Labs produces Pertussis Toxin Mutant, a genetically inactivated mutant of pertussis toxin. The Pertussis Toxin Mutant contains a modified sequence encoding the enzyme subunit. Virulence of this pertussis mutant is greatly reduced relative to that found with the wild type. The pertussis mutant protein is isolated from the TY-178 strain of Bordetella bronchiseptica which contains a genetically modified sequence encoding the S1 sub unit. Site-directed mutagenesis was used to replace amino acid residues arginine-9 with lysine (R9K) and glutamic acid-129 with alanine (E129A). Genetically inactivated toxin has reduced activity relative to the native toxin and may be used as an antigen or as a carrier to promote an immune response.
Bordetella pertussis virulence factors derived from native organisms and offered by List Labs, include Pertussis Toxin, Pertussis Toxin Subunits, Filamentous Hemagglutinin (FHA), Fimbriae 2/3, Pertactin (69 kDa protein), Adenylate Cyclase Toxin (ACT), Adenylate Cyclase Antigen and B. pertussis Lipopolysaccharide (LPS). More information about each of these products may be obtained through the links on the Bordetella Virulence Factors page.
This product is also an adjuvant. For more information on adjuvants from List Labs, read our blog.