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Page 608 out of 644

Transport of influenza virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42 proteins

Wang, S;Li, H;Chen, Y;Wei, H;Gao, GF;Liu, H;Huang, S;Chen, JL;
Product: Toxin B from Clostridium difficile

Antibodies and Reagents:

... Clostridium difficile toxin B was obtained from List Biological Laboratories (Campbell, CA). ...

Rho Family GTPases Are Required for Efficient Transport of Influenza A Virus NA to Cell Surface:

... Next, we used this established system to investigate the contribution of Rho GTPases to influenza virus NA transport to the cell surface. Rho-GTPase activity was acutely inhibited in cells treated with C. difficile toxin B, as toxin B glucosylates all members of the Rho family and inhibits their effector interactions (30, 40,–,42). ...
To further confirm these observations, we used an independent approach to test the effects of toxin B on NA transport to the plasma membranes. ...

PubMed ID: 22318733

Anthrax lethal toxin disrupts intestinal barrier function and causes systemic infections with enteric bacteria

Sun, C;Fang, H;Xie, T;Auth, RD;Patel, N;Murray, PR;Snoy, PJ;Frucht, DM;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis

In vivo intoxication experiments:

Lyophilized recombinant PA, LF, and mutant LF (E687C) were purchased from List Biological Laboratories, Inc. (Campbell, CA) and reconstituted in sterile water (stock concentration: 1 mg/mL in 5 mM HEPES, 50 mM NaCl, pH 7.5). Anthrax LT was administered with a fixed ratio of PA/LF of 2.5∶1 by weight (molar ratio: 2.7∶1). Unless otherwise indicated, mice were injected intravenously with 200 µg PA/80 µg LF (C57BL/6J) or 100 µg PA/40 µg LF (BALB/c), administered in a total volume of 0.3 mL of PBS. As a negative control, selected mice received the same volume of PBS alone. ...

Some experiments involved the concomitant administration of broad-spectrum antibiotics with anthrax LT. Both antibiotics were administered subcutaneously beginning the day of LT treatment (amoxicillin: 100 mg/kg every 8 hours, and gentamicin 16 mg/kg one time per day, Sigma, St. Louis, MO). Antibiotic therapy was maintained until the animal succumbed to toxemia or until the termination of the experiment.

Author did not indicate which specific lethal factor was utilized.  List Labs provides Product #172 (Anthrax Lethal Factor (LF), Recombinant from B. anthracis) and Product #169 (Anthrax Lethal Factor (LF-A), Recombinant from B. anthracis Native Sequence).

PubMed ID: 22438953

I-domain-antigen conjugate (IDAC) for delivering antigenic peptides to APC: synthesis, characterization, and in vivo EAE suppression

Manikwar, P;Büyüktimkin, B;Kiptoo, P;Badawi, AH;Galeva, NA;Williams, TD;Siahaan, TJ;
Product: Pertussis Toxin from B. pertussis, Lyophilized in Buffer

Induction and suppression of EAE:

Disease Stimulation

Female inbred SJL/J mice, 5–7 weeks old, were randomly divided into different groups. All mice were immunized with PLP139–151 in Freund’s complete adjuvant (CFA) to induce EAE, as reported previously.3, 4 The PLP/CFA emulsion (50 μL per site) was administered to four separate regions above the shoulder and on the flanks. In addition, 200 ng of pertussis toxin (List Biological Laboratories Inc., Campbell, CA) was injected intraperitoneally on day 0 and 2. ...

Author did not specify which List Labs Pertussis Toxin was utilized.  List Labs provides Product #180 - Pertussis Toxin from B. pertussis, Lyophilized in Buffer and Product #181 - Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free).

PubMed ID: 22369638

Targeting of prion-infected lymphoid cells to the central nervous system accelerates prion infection

Friedman-Levi, Y;Hoftberger, R;Budka, H;Mayer-Sonnenfeld, T;Abramsky, O;Ovadia, H;Gabizon, R;
Product: Pertussis Toxin from B. pertussis, Lyophilized in Buffer

Experimental autoimmune encephalomyelitis induction:

Five- to eight-week-old female C57BL/6 J mice were immunized with an emulsion containing 300 μg of MOG35-55 ... On the day of inoculation and 48 hours later, 100 ng of pertussis toxin (List Biological Laboratories, Inc. Cambell, CA, USA) in 0.1 mL saline was also administered by intraperitoneal injection. Control groups were inoculated the same way but without MOG35-55.

Author did not specify which List Labs Pertussis Toxin was utilized.  List Labs provides Product #180 - Pertussis Toxin from B. pertussis, Lyophilized in Buffer and Product #181 - Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free).

PubMed ID: 22436404

Identification of cellular infiltrates during early stages of brain inflammation with magnetic resonance microscopy

Waiczies, H;Millward, JM;Lepore, S;Infante-Duarte, C;Pohlmann, A;Niendorf, T;Waiczies, S;
Product: Pertussis Toxin from B. pertussis, Lyophilized in Buffer

Active EAE:

To actively induce EAE, 6–8 week old female SJL/J mice (Janvier, France) were immunized subcutaneously with 250 µg PLP139–151 purity >95% (Pepceuticals Ltd., UK) together with Complete Freund's Adjuvant and heat-killed Mycobacterium tuberculosis (H37Ra, Difco). Bordetella pertussis toxin (250 ng; List Biological Laboratories, US) was administered intraperitoneally at days 0 and 2. ...

Author did not specify which List Labs Pertussis Toxin was utilized.  List Labs provides Product #180 - Pertussis Toxin from B. pertussis, Lyophilized in Buffer and Product #181 - Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free).

PubMed ID: 22427887