Description

PERTACTIN

Pertactin (PRN) is a 69 kDa surface-located protein produced by Bordetella pertussis.  Due to its immunogenic and protective properties, it is included in acellular pertussis vaccines.  The contribution of this protein to Bordetella pathogenesis is under investigation; however, it appears to play a role in overcoming neutrophil-mediated clearance of Bordetella during early stages of establishing an infection.   Pertactin is one of the most polymorphic B. pertussis proteins, occurring in the population in more than 13 variations.  Pertactin offered by List is isolated from native cultures of B. pertussis strain 165.

Bordetella pertussis virulence factors derived from native organisms and offered by List Labs, include Pertussis Toxin, Pertussis Toxin Subunits, Pertussis Toxin Mutant, Filamentous Hemagglutinin (FHA), Fimbriae 2/3, Pertactin (69 kDa protein), Adenylate Cyclase Toxin (ACT), Adenylate Cyclase Antigen and B. pertussis Lipopolysaccharide (LPS).   More information about each of these products may be obtained through the links on the Bordetella Virulence Factors.