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LIPOPOLYSACCHARIDES

Purchase List Labs endotoxin or LPS for research and clinical investigation.  This material has been extracted from bacterial cell walls of E. coli O111:B4, O55:B5, O157:H7, J5 and K12; Salmonella typhimurium, Salmonella minnesota and Bordetella pertussis.  Both E. coli endotoxin and Salmonella endotoxin have been further purified to remove traces of residual protein and nucleic acids, producing the Ultra Pure LPS. Recently, we have developed proprietary chromatography methods, effectively removing traces of protein and nucleic acid from lipopolysaccharides while maintaining a consistently high concentration of endotoxin units; this product is known as List HPTTM LPS and is produced from E. coli O113.  Also available are both diphosphoryl and monophosphoryl Lipid A (MPLA) prepared from E. coli K12 D31m4 and Salmonella minnesota R595 (Re), respectively.  Lipid A, a disaccharide with fatty acid side chains, recognized by TLR4 receptors, is the component responsible for the endotoxic activity of LPS.  Removal of one phosphate group from Lipid A produces MPLA which has reduced toxicity while retaining the ability to stimulate the immune system.  MPLA is used as an adjuvant in various vaccines.  To purchase MPLA look for product #401 in the catalog of LPS.  List Labs sells LPS made in the USA.
      
Lipopolysaccharide (LPS) structure may be generally described as three linked regions.  The first structural feature is the lipid component Lipid A, primarily responsible for the effects of endotoxin.  Linked to Lipid A is the core antigen or R polysaccharide, a short chain of sugars including 2-keto 3-deoxyoctonate (KDO).  The third structural feature is attached to the core polysaccharide and is more elaborate, containing up to 40 repeating subunits of 3 to 5 sugars, referred to as the O antigen, O side chain or O polysaccharide.  Variations in the composition of the O antigen account for the species specific antibody responses.  Lipid A, acting alone or as a component of LPS, is a potent modulator of the mammalian immune response.  The presence of Lipid A or LPS in mammalian macrophages or endothelial cells triggers a signaling cascade leading to the secretion of pro-inflammatory cytokines and nitric oxide.  LPS also acts as a B cell mitogen.  Differences in Lipid A fatty acid side chain structures may be responsible for variations of the known effects on the immune system.

Product # Product Name Special Requirement Size Price Ea. QTY.
201 LPS from Escherichia coli O111:B4

MSDS not provided: Non-hazardous

Certificate of Analysis - Lot # 20143A2
Certificate of Analysis - Lot # 20144A1
Certificate of Analysis - Lot # 20144A2
Certificate of Analysis - Lot # 20143A3
Certificate of Analysis - Lot # 20146A1

Product Information - Highly Purified LPS
Product Information - Shiga Toxin
Product Information - Apoptosis

Non-Hazardous Statement

5 mg $135.00
Total: $


TERMS: Net 30 days (U.S Dollars) • VISA/MASTERCARD/AMERICAN EXPRESS ACCEPTED • F.O.B.: Campbell, CA
INTERNATIONAL CUSTOMERS: Add $50.00 service charges
THE ABOVE PRODUCTS ARE FOR RESEARCH PURPOSES ONLY AND ARE NOT FOR USE IN HUMANS.
Prices are subject to change without notice

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Pertussis Tetanus Lipopolysaccharides Cholera Difficile Shiga Anthrax Diptheria Fret peptides Native substrates Staphylococcus (SEB)
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