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APPLICATIONS

 

BACTERIAL TOXINS

 

ANTISERA, ANTIBODIES, and PEPTIDE SUBSTRATES

ACTIN CYTOSKELETON REGULATORS   Anthrax Toxins from Bacillus anthracis   SNAPtide®(U.S Patent # 6,504,006), a peptide substrate for botulinum toxin type A
ADJUVANTS AND CARRIERS   Botulinum Toxins from C. botulinum   MAPKKide® Peptide Substrate (o-Abz/Dnp) for Lethal Factor
APOPTOSIS   Cholera Toxins from V. cholerae   VAMPtide® Peptide Substrate (oAbz/Dnp) for C. botulinum type B
FRET SUBSTRATES   Difficile Toxins from C. difficile   SNAP EtideTM Peptide Substrate (o-Abz/Dnp) for C. botulinum type E
TOXOIDS   Tetanolysin from C. tetani   SNAP-25 Recombinant Protein Substrate for C. botulinum Type A and E neurotoxin
IMMUNE RESPONSE MODULATORS   Neurominidase from Vibrio cholerae   Goat Anti-Exotoxin A Antibody for Exotoxin A from P. aeruginosa
MEMBRANE TRAFFIC ALTERERS   Diphtheria Toxins and CRM197 from C. diphtheriae   Goat Anti-Choleragenoid Antibody for Cholera Toxin B Subunit
METALLOPROTEASE INHIBITORS   Pertussis Toxins from B. pertussis   Goat Anti-Toxin A Antibody for Toxin A from Clostridium difficile
NEURONAL MARKERS   Shiga Like Toxins from E. coli   Anti-Shiga Like Toxin 1 and 2 (Mouse IgG1-K) Monoclonal
PORE FORMERS   Tetanus Toxins from C. tetani   Goat Anti-PA, Anti-LF, and Anti-EF from Bacillius anthracis
PROTEIN SYNTHESIS INHIBITORS   Alpha toxin from S. aureus   Anti-Adenylate Cyclase Toxin Murine Monoclonal Antibody 3D1
RECEPTORS   Enterotoxin type B from S. aureus   Anti-RTX Murine Monoclonal Antibody 9D4
SCREENING FOR BOTULINUM TOXIN INHIBITORS   Pasteurella Multocida Toxin   RECOMBINANT PROTEINS and MORE TOXINS
SIGNAL TRANSDUCTION   Exotoxin A from P. aeruginosa   Botulinum Neurotoxin Light Chain Type A, B, C, D, E and F
SUPERANTIGENS   Adenylate Cyclase Toxin from B. pertussis   Tetanus Toxin Light Chain
LIPOPOLYSACCHARIDES       FHA


Posters:

Internally Quenched Fluorogenic Substrates for Anthrax Lethal Factor. N. Shine, L. Eaton, K. Crawford - presented at the 5th International Conference on Anthrax, March 30, 2003 in Nice, France.

Rapid, Sensitive and Specific Assay to Measure the Endoprotease Activity of Botulinum Toxin Type A. N. Shine, T. Christian, L. Eaton, K. Crawford - presented at the 5th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins, June 2005 in Denver, Colorado, USA.

Comparison of Activity of Botulinum Neurotoxin Type A Holotoxin and Light Chain Using SNAPtideR FRET Substrates. T. Christian, N. Shine, L. Eaton, K. Crawford - presented at the 5th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins, June 2005 in Denver, Colorado, USA.

Sensitive and Specific Assay to Measure Endoprotease Activity of Botulinum Toxin Type A Holotoxin in Milk. Nancy Shine, Linda Eaton, and Karen Crawford presented at the 42nd Annual IBRCC, December 5-8, 2005 in Baltimore, Maryland.

Physical Characteristics of rLF and rPA: Effects on Enzymatic Activity and Binding. Nancy Shine, Cindy Le, Linda Eaton, and Karen Crawford presented at Bacillus Act 2005, September 25-29, 2005 in Sante Fe, New Mexico.

SNAP Etide, a FRET Substrate for Botulinum Toxin Type E. Yuliya Primak, Todd Christian, and Nancy Shine presented at the 43nd Annual IBRCC, November 14-17, 2006 in Silver Springs, Maryland.

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